Dedifferentiated liposarcoma (DDLPS) is a rare subtype of retroperitoneal sarcoma (RPS) arising from mesenchymal tissue, commonly in fat-rich regions such as the retroperitoneum. We present a case of DDLPS in a 61-year-old male who presented with an abdom

Abstract

Dedifferentiated liposarcoma (DDLPS) is a rare subtype of retroperitoneal sarcoma (RPS) arising from mesenchymal tissue, commonly in fat-rich regions such as the retroperitoneum. We present a case of DDLPS in a 61-year-old male who presented with an abdominal mass, weight loss, and anorexia. Surgical management involved complete tumor excision with right radical nephrectomy. Histopathology and immunohistochemistry revealed MDM2-positive dedifferentiated liposarcoma, with a probable origin from the perirenal fat pad. This case underscores the challenges in diagnosing and managing RPS and highlights the importance of histological and molecular diagnostics in guiding treatment.