COMPARATIVE EVALUATION OF BONE MARROW ASPIRATION AND TREPHINE BIOPSY: INSIGHTS FROM AN OBSERVATIONAL STUDY

Abstract

Bone marrow aspiration (BMA) and bone marrow trephine biopsy (BMB) are crucial diagnostic procedures in hematology, providing complementary insights into marrow pathology. BMA offers detailed cytological evaluation and facilitates ancillary studies, while BMB assesses marrow architecture, stromal alterations, fibrosis, and focal infiltrates. BMA identifies pathology in cases where BMA may be limited, while BMB detects early cytological abnormalities missed by BMB. The combined use of both techniques increases diagnostic yield to over 95%. Disease-specific considerations influence procedural choice, with BMA preferred in acute leukemias and BMB in myeloproliferative neoplasms.