STUDY OF ACID PEPTIC DISEASE WITH H PYLORI INFECTION IN CASES OF CALCULOUS CHOLECYSTITIS IN A TERTIARY CARE HOSPITAL

Abstract

Background: Helicobacter pylori (H. pylori) infection is primarily associated with gastric diseases but has been implicated in extra-gastric conditions, including gallbladder diseases such as chronic calculous cholecystitis. Understanding the prevalence and clinical implications of H. pylori in these patients is crucial for effective management.

Methods: We conducted a retrospective cohort study from January 2023 to March 2024 at a tertiary care hospital to investigate the prevalence of H. pylori infection among patients diagnosed with calculous cholecystitis. Clinical data, including demographic information, H. pylori status determined by upper gastrointestinal endoscopy, gastritis severity, and procedural details, were analyzed.

Results: Among 50 patients included in the study, the prevalence of H. pylori infection was 24.0%, which was lower than previously reported rates. Significant associations were observed between H. pylori infection and the severity of gastritis (p = 0.011), indicating a potential role of bacterial infection in gallbladder inflammation. No significant association was found between H. pylori infection and the presence of intestinal metaplasia or the type of surgical procedure performed.

Conclusion: Our findings suggest that H. pylori may contribute to chronic cholecystitis through mechanisms involving gastric inflammation, although its exact role in gallbladder pathology requires further investigation. Screening for H. pylori in patients with chronic calculous cholecystitis, particularly those with severe gastritis, may aid in targeted management strategies to improve clinical outcomes.