COMPARISON OF MEAN BLOOD LOSS IN FEMALES UNDERGOING VAGINAL DELIVERY AT TERM WITH AND WITHOUT TRANEXAMIC ACID

Abstract

Objective: To compare the mean loss of blood in females giving birth naturally at term with and without tranexamic acid.

Study Design: Randomized controlled trial.

Place and Duration of Study: Department of Obstetrics and Gynaecology, Sir Ganga Ram Hospital, Lahore, from August 2025 to November 2025.

Methodology: A random sample of 92 females between 18 and 40 years old diagnosed with term pregnancy 37 weeks and above were randomly divided into two equal groups. Active management of third stage of labor using oxytocin 10 units IM and tranexamic acid 1 gram slow IV was done to Group A (n=46). Group B (n=46) was treated to oxytocin 10 units IM only. Demographic and clinical variables at the baseline were measured. The patients participated in the measurement of blood loss immediately with the help of graduated bags (100-ml graduations). SPSS version 25.0 was used in analyzing the data. Mean and standard deviation were used to represent the quantitative variables, and frequency and percentage were used to represent qualitative variables.

Results: The average age of the patients was 35.42 8.50 years, and average gestational age was 38.65 0.95 weeks. Blood loss at 15 minutes was significantly less in the tranexamic acid group than in the control one. When stratified by age, parity, and BMI, it was found that blood loss reduced equally when the tranexamic acid was used.

Conclusion: The usage of tranexamic acid has shown a significant impact on the mean blood loss in term vaginal delivery of females.