EXPLORING THE EFFECTS OF EXCIPIENTS ON DRUG STABILITY AND BIOAVAILABILITY

Abstract

The physiognomies of the pharmaceuticals and the likelihood of consistent and repeatable clinical effects are typically the basis for a doctor's prescriptions.  Nonetheless, it is typical for patients to respond differently to medications, which frequently makes it difficult to customize a dosage schedule for each patient.  Drugs are frequently taken through a variety of ways, however the oral route is highly recommended because to its appropriateness, relative affordability, and high patient compliance rate.  On the other hand, before oral dose forms may reach their precise site of action, they must dissolve in gastrointestinal fluids, absorb through intestinal epithelia, and undergo liver metabolism.The release of the active ingredient from the formulation, the rate of dissolution, the stability of the drug candidate in the gastrointestinal (GI) atmosphere, permeability, and metabolism in the gut wall and liver are some of the factors that contribute to the low and variable oral bioavailability because of this lengthy pathway.