EVALUATION OF ALBIZIA GUM, DAMMAR GUM AND MOI GUM IN THE FORMULATION OF CONTROLLED RELEASE MATRIX TABLETS USING FUROSEMIDE

Abstract

Background: Natural gums like albizia gum, dammar gum and moi gum were used in this work for the preparation of matrix tablets.

Objective: The main objective of the present work is to study the suitability of albizia gum, dammar gum and moi gum in different proportions for the preparation of controlled release matrix tablets using water insoluble drug like furosemide.

Method: Matrix tablets were prepared by direct compression method by using water soluble diluent like lactose and water insoluble diluent like dibasic calcium phosphate.

Results:In vitro release studies were performed in 0.1 N HCl for the first two hours and pH 6.8 phosphate buffer for the next ten hours. The retardation of drug release was influenced by concentration of gum and nature of diluents. No interaction between drug and gums were observed by using FTIR and DSC studies.

Conclusion: Among the selected three gum’s dammar gum showed 100% drug release within 12 hrs and fallowed zero order kinetics with non-Fickian diffusion.