THE ANTIMICROBIAL ACTIVITY AND CYTOTOXIC EFFECT OF MOMORDICA CHARANTIA MEDIATED HAFNIUM OXIDE NANOPARTICLES

Abstract

Aim : The field of nanobiomedicine and nanotechnology are mostly inter-related in todays world.Functionalised Hafnium Oxide nanoparticles (HfONPs) being a single agent in HNSCC exhibit potent antimicrobial properties.The various health benefits of Momordica Charantia renders it a very good anti-oxidant and anti-cancer property.The aim of the study is to prepare a Momordica Charantia mediated hafnium oxide nanoparticles and to assess the antimicrobial activity and cytotoxic effect. Materials and method: sThe Momordica Charantia extract was used in the synthesis of hafnium oxide nanoparticles.These green synthesised hafnium oxide nanoparticles using Momordica Charantia were tested for characterisation using X-ray diffraction and FTIR analysis and biomedical applications using antimicrobial activity in agar well diffusion method and cytotoxic effect in brine shrimph lethality assay.  Results: The Momordica charantia synthesised hafnium oxide nanoparticles showed maximum zone of inhibition of 18 mm in C. albicans at 100µg/mL and the cytotoxic effect showed minimal toxicity at 80µg/mL Conclusion: In the current study, Momordica Charantia synthesised hafnium oxide nanoparticles showed antimicrobial activity especially in Candida albicans and cytotoxic effect showed minimal toxicity.