MRNA- BASED CANCER VACCINES TARGETING TUMOR ASSOCIATED MACROPHAGES: REPROGRAMMING THE TUMOR MICROENVIRONMENT FOR ENHANCED IMMUNOTHERAPY

Authors

  • BONEY PRIYA P JOSE DEPARTMENT OF DERMATOLOGY, VENEREOLOGY AND LEPROSY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • AKSHAYA VISWANATHAN DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • NEHA BRAHMA DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • VIMAL S DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA
  • DR. KISHORE KUMAR VICE PRINCIPAL & PROFESSOR, DEPARTMENT OF ORTHODONTICS & DENTOFACIAL ORTHOPEDICS, SREE BALAJI DENTAL COLLEGE & HOSPITAL, CHENNAI, INDIA

Keywords:

mRNA Vaccine, Tumor-Associated Macrophages, Macrophage Polarization, Tumor Microenvironment, Lipid Nanoparticles, Immunotherapy, Immune Reprogramming, Checkpoint Blockade

Abstract

Cancer immunotherapy is limited by the immunosuppressive tumor microenvironment (TME), largely shaped by tumor-associated macrophages (TAMs). mRNA-based vaccines offer a novel strategy to reprogram TAMs from a tumor-promoting M2 to a tumoricidal M1 phenotype. Delivered via targeted lipid nanoparticles, these vaccines enhance anti-tumor immunity and synergize with checkpoint inhibitors. This approach holds promise for converting “cold” tumors into “hot,” improving outcomes in resistant cancers.

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How to Cite

JOSE, B. P. P., VISWANATHAN, A., BRAHMA, N., S, V., & KUMAR, D. K. (2025). MRNA- BASED CANCER VACCINES TARGETING TUMOR ASSOCIATED MACROPHAGES: REPROGRAMMING THE TUMOR MICROENVIRONMENT FOR ENHANCED IMMUNOTHERAPY. TPM – Testing, Psychometrics, Methodology in Applied Psychology, 32(S2(2025) : Posted 09 June), 764–767. Retrieved from https://tpmap.org/submission/index.php/tpm/article/view/296

Issue

Vol. 32 No. S2(2025) : Posted 09 June (2025)

Section

Articles

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