FUTURE DIRECTIONS IN BREAST CANCER DIAGNOSIS: THE EXPANDING LANDSCAPE OF LIQUID BIOPSY- BASED BIOMARKERS

Authors

  • AKSHAYA VISWANATHAN DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA
  • PRABAKARAN B DEPARTMENT OF PATHOLOGY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • NEHA BRAHMA DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • VIMAL S DEPARTMENT OF BIOCHEMISTRY, SAVEETHA MEDICAL COLLEGE, SAVEETHA INSTITUTE OF MEDICAL AND TECHNICAL SCIENCES, SAVEETHA UNIVERSITY, CHENNAI, TAMIL NADU, INDIA.
  • DR.GOLD PEARLIN MARY READER, DEPARTMENT OF CONSERVATIVE DENTISTRY & ENDODONTICS, SREE BALAJI DENTAL COLLEGE & HOSPITAL, CHENNAI, INDIA

Keywords:

Liquid biopsy, Breast cancer, Circulating tumor DNA (ctDNA), Non-coding RNAs, Extracellular vesicles (EVs)

Abstract

Breast cancer diagnosis is advancing through liquid biopsy, a minimally invasive method analyzingtumor-derived biomarkers in blood. Circulating tumor DNA (ctDNA), CTCs, EVs, and ncRNAs offer real-time insights into tumor dynamics, resistance, and subtypes. ctDNA enables early detection of recurrence, while ncRNA signatures guide prognosis and therapy. Integration with genomic strategies, such as using PARP inhibitors in BRCA1/2-deficient tumors, enhances treatment precision. This approach exploits synthetic lethality, selectively killing cancer cells while sparing normal ones. Emerging AI-driven multi-omics platforms promise personalized monitoring. Together, these innovations are reshaping breast cancer care.

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How to Cite

VISWANATHAN, A., B, P., BRAHMA, N., S, V., & MARY, D. P. (2025). FUTURE DIRECTIONS IN BREAST CANCER DIAGNOSIS: THE EXPANDING LANDSCAPE OF LIQUID BIOPSY- BASED BIOMARKERS. TPM – Testing, Psychometrics, Methodology in Applied Psychology, 32(S2(2025) : Posted 09 June), 439–442. Retrieved from https://tpmap.org/submission/index.php/tpm/article/view/260

Issue

Vol. 32 No. S2(2025) : Posted 09 June (2025)

Section

Articles

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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.