HIGH DOSE VITAMIN D SUPPLEMENTATION AS ADJUVANT THERAPY IN THE MANAGEMENT OF DIABETIC FOOT ULCERS

Abstract

Objective: This study aimed to assess the impact of high-dose vitamin D supplementation as an adjunctive treatment in diabetic foot ulcer (DFU) management. Methods: Relevant literature was searched in PubMed, ScienceDirect, ClinicalTrial, and Google Scholar databases from inception until May 2025. Eligible studies included randomized controlled trials (RCTs), interventional research, or studies with a comparator group. The primary outcomes considered were ulcer reduction and healing. Results: Five RCTs involving 245 participants were included. Most of the trials demonstrated greater ulcer reduction in the intervention groups compared with controls. Furthermore, high-dose vitamin D supplementation was associated with significantly higher healing rates than low-dose regimens. No significant adverse events were reported. Conclusions: High-dose vitamin D supplementation significantly enhances wound healing in DFU patients by reducing ulcer area. Greater doses produced more favorable healing outcomes compared with lower doses.