ENHANCED ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF GREEN-SYNTHESIZED SELENIUM NANOPARTICLES USING MOMORDICA CYMBALARIA

Abstract

This study aimed to synthesize and evaluate the antidiabetic and antioxidant activities of selenium nanoparticles (SeNPs) prepared using Momordica cymbalaria extract, a plant known for its medicinal properties. The extract was employed in a green synthesis approach to produce SeNPs, which were then characterized and assessed for biological activity. UV-Vis spectroscopy confirmed the formation of the nanoparticles through characteristic absorption peaks. The synthesized SeNPs exhibited significant α-amylase and α-glucosidase inhibitory activities, indicating their potential as antidiabetic agents. Additionally, they demonstrated notable antioxidant activity in both DPPH and ABTS assays, suggesting their ability to combat oxidative stress. These findings highlight that selenium nanoparticles synthesized using Momordica cymbalaria possess promising therapeutic potential. The green synthesis method not only offers an eco-friendly approach to nanoparticle production but also enhances the bioactivity of selenium by integrating the plant’s bioactive compounds. Further in vivo studies are necessary to validate their efficacy and safety for clinical applications.