EFFECTIVENESS OF INTRAVENOUS TRANEXAMIC ACID ADMINISTRATION ON HOSPITAL OUTCOMES AND MORTALITY REDUCTION AMONG BLUNT TRAUMA PATIENTS IN A TERTIARY CARE HOSPITAL, KANCHIPURAM DISTRICT, TAMIL NADU

Abstract

Background:
Blunt trauma is a major cause of morbidity and mortality in emergency medicine. Timely administration of antifibrinolytic agents such as tranexamic acid (TXA) has demonstrated promise in improving outcomes among trauma patients. This study evaluates the effectiveness of intravenous TXA administration in reducing mortality and improving hospital outcomes among blunt trauma patients in a tertiary care hospital in Kanchipuram District, Tamil Nadu.

Objectives:
To assess the impact of intravenous TXA on mortality reduction among blunt trauma patients and to compare clinical outcomes between those who received TXA and those who did not in the same hospital setting.

Methods:
A cross-sectional study was conducted involving 128 blunt trauma patients aged >18 years who were admitted to the hospital and received intravenous TXA. Patients with significant comorbidities such as end-stage liver disease or kidney failure were excluded. Data were collected on demographic variables (age, gender, injury severity, mechanism of injury) and clinical indicators (vital signs, injury severity score, Glasgow Coma Scale, hemoglobin, hematocrit, and platelet count). Hospital outcomes, including mortality rates, were analyzed using Microsoft Excel and SPSS. Bivariate analysis was performed using Chi-square tests for categorical variables and t-tests and ANOVA for continuous variables.

Results:
The study aims to elucidate the differences in mortality and other hospital-related outcomes between the TXA-treated and non-TXA-treated patient groups, providing insight into the clinical utility of TXA in trauma care.

Conclusion:
The findings are expected to support the role of intravenous tranexamic acid in improving trauma outcomes. Implementation of TXA in trauma protocols may lead to better resource utilization, improved patient survival, and enhanced trauma care practices in tertiary healthcare settings.