A SYSTEMATIC REVIEW OF THE PALLIATIVE CARE IN PATIENTS WITH ADVANCED COLORECTAL CANCER; FAMILY MEDICINE PHYSICIAN’S PERSPECTIVES

Abstract

Objectives: To aggregate and analyze the existing body of research surrounding palliative care for patients with advanced colorectal cancer (CRC).

Methods: A comprehensive search of four databases led to the discovery of 711 relevant publications. After eliminating duplicates with Rayyan QCRI and assessing each article for relevance, 131 full-text articles were examined, and ultimately, 7 studies were selected based on the inclusion criteria.

Results: We included seven studies with a total of 2649 patients with CRC, of whom 1408 (53.2%) were males.  Palliative chemotherapy demonstrated improved survival compared to best supportive care. Primary tumor resection (PTR) was an independent predictor of better OS, regardless of tumor location. Systemic therapy followed by radiotherapy also showed survival benefits. Structured palliative care programs improved prognostic awareness and advance care planning. Comparable survival outcomes were observed between young-onset and older mCRC patients. ‘

Conclusion: Palliative interventions, when individualized and integrated early, offer meaningful benefits in mCRC management. A multidisciplinary, patient-centered approach is essential for optimizing outcomes. Further research is needed to standardize treatment pathways and refine prognostic tools.