MARINE-DERIVED COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

Abstract

The maritime environment has a wealth of highly active chemicals with strong biological activity.   Most recently published review publications categorize marine chemical patents according to their evolutionary tree.   This review focuses on the possibility of marine natural compounds as a source of new drugs for the treatment of neurological diseases.   The current review focuses on two conditions that are successful in the field: neuro-pathic pain and Alzheimer's disease.  Here, patents from 1998 to 2004 are included.   Neuroinflammation is one of the basic pathogenic characteristics of a widely diverse range of neurological diseases, as observed in conditions such as Parkinson's, multiple sclerosis, Alzheimer's, and Huntington's disease. There is increasing interest in developing novel treatments that target the underlying neuroinflammatory processes, even though the majority of current treatments for these conditions are symptomatic.   This review discusses the present status of research on the neuroprotective qualities of compounds found in marine invertebrates and their possible therapeutic use in the treatment of neuroinflammatory diseases.   We also discussed the challenges and disadvantages of using marine-derived materials as medicine, such as supply and sustainability concerns, as well as the need for additional preclinical and clinical research to confirm their safety and effectiveness.