STUDY OF CENTRAL CORNEAL THICKNESS (CCT) IN DIABETICS IN EUGLYCEMIC STATE AND HYPERGLYCEMIC STATE

Abstract

Diabetes Mellitus is characterized by chronic hyperglycemia, leading to systemic complications affecting various organs, including the cornea. This prospective longitudinal observational study aimed to investigate changes in Central Corneal Thickness (CCT) among Type 2 diabetics in hyperglycemic and euglycemic states over a one-month period. A total of 90 diabetic subjects were enrolled, with CCT  within 30 mins  of post-prandial blood sugar (PPBS) measurements. Follow-up assessments were conducted after one month to evaluate CCT changes under euglycemic conditions, defined as PPBS < 200 mg/dl with at least 50 mg/dl reduction from hyperglycemic levels.

Results: indicated no significant difference in CCT between hyperglycemic and euglycemic states (p > 0.05). Furthermore, there was no correlation found between changes in blood sugar levels and CCT alterations. Short-term fluctuations in blood sugars did not influence CCT in diabetic patients within the study period. Additionally, routine Intraocular Pressure (IOP) measurements were unaffected by short-term variations in blood sugar levels.

In conclusion, this study suggests that short-term glycemic fluctuations may not impact corneal thickness or routine IOP measurements in Type 2 diabetes, highlighting the stable nature of these ocular parameters despite glycemic variability over one month.